Malignant peripheral nerve sheath tumor mpnst is an aggressive soft tissue sarcoma arising from the peripheral nerve sheath 1 2 more than 50 of these tumors arise from a preexisting plexiform neurofibroma in patients with neurofibromatosis nf type 1 3 4 treatment strategy of mpnsts includes surgery high dose adjuvant chemotherapy and radiotherapy. Malignant pnst in 29 years. Photo courtesy of stone source.
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